Pipkin G A, Mills J G
Dept. of Gastroenterology, Glaxo Wellcome Research and Development, Uxbridge, UK.
Scand J Gastroenterol Suppl. 1999;230:3-8.
The majority of patients who have symptomatic acid reflux disease will have a normal oesophageal mucosa or will have only a mild degree of oesophagitis. Treatment to relieve symptoms as they occur may be the best way to manage these patients, to whom the speed of symptom relief is of primary importance. The effervescent complex used to formulate effervescent ranitidine contains sodium bicarbonate and monosodium citrate, and has, therefore, an intrinsic acid-neutralizing capacity in addition to the well-documented antisecretory activity.
The results of studies of the effects of effervescent ranitidine tablets on intragastric pH and on the relief of heartburn are reviewed.
When compared with the standard ranitidine tablet, the effervescent formulation results in a significantly greater and more rapid rise in intragastric pH in the hour immediately after dosing. Comparative studies show that intragastric pH is raised significantly faster after a single dose of effervescent ranitidine than after a famotidine rapid release tablet and after either an omeprazole or a lansoprazole capsule. In patients with acid reflux disease, effervescent ranitidine provides quicker relief of symptoms than a standard tablet and is preferred by most patients for this reason. The majority of patients (more than 80%) report symptom relief within 60 min of taking effervescent ranitidine.
大多数有症状性胃酸反流疾病的患者食管黏膜正常，或仅有轻度食管炎。在症状出现时进行缓解症状的治疗可能是管理这些患者的最佳方法，对他们来说，症状缓解的速度至关重要。用于配制泡腾雷尼替丁的泡腾复合物含有碳酸氢钠和柠檬酸一钠，因此，除了有充分记录的抗分泌活性外，还具有内在的酸中和能力。
综述泡腾雷尼替丁片对胃内pH值及烧心缓解作用的研究结果。
与标准雷尼替丁片相比，泡腾制剂在给药后立即的1小时内可使胃内pH值显著升高且升高速度更快。比较研究表明，单剂量泡腾雷尼替丁后胃内pH值升高速度明显快于法莫替丁速释片以及奥美拉唑或兰索拉唑胶囊。在胃酸反流疾病患者中，泡腾雷尼替丁比标准片剂能更快缓解症状，因此大多数患者更喜欢使用。大多数患者（超过80%）报告在服用泡腾雷尼替丁后60分钟内症状得到缓解。
