Krichevets S G, Varich N L, Rudneva I A, Kaverin N V
Vopr Virusol. 1999 Jul-Aug;44(4):158-62.
Human and avian influenza A strains with a known amino acid sequence of NP protein were studied in radioimmunoprecipitation test with a panel of anti-NP monoclonal antibodies. Two of 7 MAbs (315 and IVE8) reacted with variable epitopes. One of the epitopes was present only in human strains, while the other in both human and avian strains, but absent in gull strains and in one human strain, A/Puerto Rico/8/34 (H1N1). The variations recognized by antibodies 315 and IVE8 correlated with amino acid substitutes in positions 16 and 353, respectively.
利用一组抗核蛋白（NP）单克隆抗体，通过放射免疫沉淀试验对已知NP蛋白氨基酸序列的人源和禽源甲型流感病毒株进行了研究。7种单克隆抗体中的2种（315和IVE8）与可变表位发生反应。其中一个表位仅存在于人源毒株中，另一个表位则同时存在于人源和禽源毒株中，但在鸥源毒株和一株人源毒株A/波多黎各/8/34（H1N1）中不存在。抗体315和IVE8识别的变异分别与第16位和第353位的氨基酸替代有关。
