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[利用针对M1和NP蛋白的单克隆抗体，通过免疫酶分析数据的数学处理确定甲型（H2）流感病毒之间的抗原相互关系]

[The antigenic interrelationships between influenza A (H2) viruses determined by the mathematical processing of the data from immunoenzyme analysis using monoclonal antibodies to the M1 and NP proteins].

作者信息

Govorkova E A, Kibardin V M, Kizina A A, Bucher D, Smirnov Iu A

出版信息

Vopr Virusol. 1992 Mar-Apr;37(2):99-103.

PMID:1279897
Abstract

Antigenic relationships among 15 influenza A (H2) virus strains of human and avian origin were determined by ELISA titers with monoclonal antibodies (MCA) to Ml and NP proteins. Minor antigenic variations were found in Ml protein. One MCA to NP protein (469/6) showed different reactivity with human and avian influenza viruses. Analyses of antigenic relationships among influenza viruses were performed according to a computerized taxonomic cluster procedure. The evolutionary relatedness of these viruses is discussed.

摘要

通过使用针对M1和NP蛋白的单克隆抗体（MCA）进行ELISA滴定，确定了15株人源和禽源甲型流感（H2）病毒株之间的抗原关系。在M1蛋白中发现了微小的抗原变异。一种针对NP蛋白的MCA（469/6）对人流感病毒和禽流感病毒表现出不同的反应性。根据计算机分类聚类程序对流感病毒之间的抗原关系进行了分析。并讨论了这些病毒的进化相关性。

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