[针对核蛋白（NP）的单克隆抗体及其在甲型流感病毒研究中的应用]
[Monoclonal antibodies to NP protein and their use in studying influenza A viruses].
作者信息
L'vov D K, Bukrinskaia A G, Iamnikova S S, Kras'ko A G, Vikhrev N E
出版信息
Vopr Virusol. 1986 Nov-Dec;31(6):655-7.
PMID:3548066
Abstract
Monoclonal antibodies to NP-proteins of influenza A/sea gull/Kazakhstan/470/79 (H1N1) virus have been prepared. Each clone interacted with spatially non-overlapping antigenic sites of NP-protein. The clones differed in their capacity to inhibit the polymerase activity of different influenza A virus strains. F-81 clone was shown to interact actively with NP of human influenza A viruses, clone H12 reacted with both human and animal influenza viruses.
摘要
已制备出针对甲型/海鸥/哈萨克斯坦/470/79（H1N1）病毒核蛋白（NP）的单克隆抗体。每个克隆与NP蛋白的空间不重叠抗原位点相互作用。这些克隆在抑制不同甲型流感病毒株聚合酶活性的能力上有所不同。F - 81克隆显示与人类甲型流感病毒的NP有积极的相互作用，H12克隆则与人类和动物流感病毒都有反应。
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