Haberkamp T J, Tanyeri H M
Department of Otolaryngology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
Am J Otol. 1999 Sep;20(5):587-92; discussion 593-5.
To determine if any consensus exists regarding the efficacy of treatment in idiopathic sudden sensorineural hearing loss syndrome (ISSNHL).
A review of the literature from 1966 to the present on Medline database was performed with the following search criteria: Hearing loss, sensorineural (MeSH terms), sensorineural hearing loss (text word), deafness (MeSH), and idiopathic or sudden (all fields). Further limiting search terms were treatment outcomes or controlled studies.
The articles were then analyzed searching for randomized, prospective, controlled studies of single treatment modalities. Both human and animal studies were included for discussion because of the paucity of human studies.
No consensus exists on the effective treatment of ISSNHL. Randomized, controlled studies have demonstrated the effectiveness of systemic steroids, however, follow up studies have questioned the benefit of steroid therapy.
确定在特发性突发性感音神经性听力损失综合征（ISSNHL）的治疗效果方面是否存在共识。
使用以下检索标准对1966年至今Medline数据库中的文献进行回顾：听力损失、感音神经性（医学主题词）、感音神经性听力损失（文本词）、耳聋（医学主题词）以及特发性或突发性（所有字段）。进一步限制检索词为治疗结果或对照研究。
然后对文章进行分析，寻找单一治疗方式的随机、前瞻性、对照研究。由于人体研究较少，因此讨论中纳入了人体和动物研究。
在ISSNHL的有效治疗方面不存在共识。随机对照研究已证明全身用类固醇有效，然而，后续研究对类固醇疗法的益处提出了质疑。
