Loh E, Hood J M, Riblet R, Weigert M, Hood L
J Immunol. 1979 Jan;122(1):44-8.
The N-terminal sequences from heavy variable regions of 47 myeloma proteins of the NZB mouse have been analyzed. Sixteen of these VH regions have unblocked alpha amino groups and have been analyzed over their N-terminal 20 residues by automatic sequence analysis. These sequence data along with the antigen-binding profiles and immunoglobulin class distribution are compared with comparable data from BALB/c myeloma proteins. These comparisons suggest that the NZB and BALB/c populations of myeloma proteins are distinct from one another. The genetic implications of this conclusion are discussed.
对NZB小鼠的47种骨髓瘤蛋白重链可变区的N端序列进行了分析。其中16个VH区的α氨基未被封闭，并通过自动序列分析对其N端的20个残基进行了分析。将这些序列数据以及抗原结合谱和免疫球蛋白类别分布与来自BALB/c骨髓瘤蛋白的可比数据进行了比较。这些比较表明，NZB和BALB/c骨髓瘤蛋白群体彼此不同。讨论了这一结论的遗传学意义。
