来自新西兰黑鼠（NZB）和BALB/c小鼠的骨髓瘤蛋白：结构与功能差异
Myeloma proteins from NZB and BALB/c mice: structural and functional differences.
作者信息
Loh E, Black B, Riblet R, Weigert M, Hood J M, Hood L
出版信息
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1395-9. doi: 10.1073/pnas.76.3.1395.
Abstract
Structural and functional analyses of myeloma immunoglobulins from inbred BALB/c mice and humans have provided important insights into the structure of the antibody molecule and the expression and evolution of antibody genes. One important question concerning these analyses is whether the myeloma process selects, in a nonrandom manner, the lymphocytes to be transformed. The availability of myeloma tumors in a second inbred strain of mouse, NZB, permits us to approach this question. In this respect. the NH2-terminal amino acid sequences of 27 kappa light chains as well as data relating to the antigen-binding properties and immunoglobulin class distribution of NZB myeloma proteins are presented and compared with similar data from the BALB/c mouse. These studies suggest that the myeloma proteins from the BALB/c and NZB mice constitute two populations of immunoglobulins with distinct functional and structural properties. The implication of this observation are discussed.
摘要
对近交系BALB/c小鼠和人类骨髓瘤免疫球蛋白的结构与功能分析，为深入了解抗体分子的结构以及抗体基因的表达与进化提供了重要见解。关于这些分析的一个重要问题是，骨髓瘤形成过程是否以非随机方式选择要转化的淋巴细胞。在第二种近交系小鼠NZB中存在骨髓瘤肿瘤，这使我们能够探讨这个问题。在这方面，本文给出了27种κ轻链的氨基末端氨基酸序列，以及与NZB骨髓瘤蛋白的抗原结合特性和免疫球蛋白类别分布相关的数据，并与来自BALB/c小鼠的类似数据进行了比较。这些研究表明，来自BALB/c和NZB小鼠的骨髓瘤蛋白构成了具有不同功能和结构特性的两类免疫球蛋白。本文讨论了这一观察结果的意义。
相似文献
1
Myeloma proteins from NZB and BALB/c mice: structural and functional differences.来自新西兰黑鼠（NZB）和BALB/c小鼠的骨髓瘤蛋白：结构与功能差异
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1395-9. doi: 10.1073/pnas.76.3.1395.
2
3
Evidence for 65 electrophoretically distinct groups of light chains in BALB/c and NZB myelomas.BALB/c和NZB骨髓瘤中65种电泳性质不同的轻链类型的证据。
Mol Immunol. 1984 May;21(5):421-32. doi: 10.1016/0161-5890(84)90040-3.
4
IgA polymorphism in mice: NZB and BALB/c mice produce two forms of IgA.小鼠中的IgA多态性：NZB和BALB/c小鼠产生两种形式的IgA。
Mol Immunol. 1983 Sep;20(9):983-8. doi: 10.1016/0161-5890(83)90039-1.
5
The structure and genetics of mouse immunoglobulins: an analysis of NZB myeloma proteins and sets of BALB/c myeloma proteins binding particular haptens.小鼠免疫球蛋白的结构与遗传学：对NZB骨髓瘤蛋白及结合特定半抗原的BALB/c骨髓瘤蛋白组的分析。
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:817-36. doi: 10.1101/sqb.1977.041.01.092.
6
Mutations in mouse myeloma cells: implications for human multiple myeloma and the production of immunoglobulins.小鼠骨髓瘤细胞中的突变：对人类多发性骨髓瘤及免疫球蛋白产生的影响。
Ann Intern Med. 1976 Jul;85(1):110-6. doi: 10.7326/0003-4819-85-1-110.
7
Origins of antibody complementarity and specificity--hypervariable regions and minigene hypothesis.抗体互补性与特异性的起源——高变区与小基因假说
J Immunol. 1980 Sep;125(3):961-9.
8
Autoreactive responses to an environmental factor. 2. Phthalate-induced anti-DNA specificity is downregulated by autoreactive cytotoxic T cells.对环境因子的自身反应性应答。2. 邻苯二甲酸酯诱导的抗DNA特异性被自身反应性细胞毒性T细胞下调。
Immunology. 2004 May;112(1):94-104. doi: 10.1111/j.1365-2567.2004.01842.x.
9
An allotypic specificity on the CH1 domain of mouse IgA.小鼠IgA的CH1结构域上的同种异型特异性。
J Immunol. 1982 Nov;129(5):2040-1.
10
Immunoglobulin isoantigens (allotypes) in the mouse. II. Allotypic analysis of three gammaG2-myeloma proteins from (NZB x BALB/c)F1 hybrids and of normal gammaG2-globulins.小鼠中的免疫球蛋白同种抗原（同种异型）。II. 来自（NZB×BALB/c）F1杂种的三种γG2-骨髓瘤蛋白及正常γG2-球蛋白的同种异型分析。
J Exp Med. 1966 Apr 1;123(4):707-21. doi: 10.1084/jem.123.4.707.
引用本文的文献
1
Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.免疫球蛋白轻链基因重排、受体编辑和自身耐受抗体库的形成。
Front Immunol. 2018 Oct 8;9:2249. doi: 10.3389/fimmu.2018.02249. eCollection 2018.
2
Sequence diversity within a subgroup of mouse immunoglobulin kappa chains controlled by the IgK-Ef2 locus.由IgK-Ef2基因座控制的小鼠免疫球蛋白κ链亚组内的序列多样性。
J Exp Med. 1981 Jul 1;154(1):146-55. doi: 10.1084/jem.154.1.146.
3
Unique V kappa group associated with two mouse L chain genetic markers.与两个小鼠轻链遗传标记相关的独特Vκ基因群
Proc Natl Acad Sci U S A. 1981 Jan;78(1):559-63. doi: 10.1073/pnas.78.1.559.
4
A major group of mouse kappa chains controlled by the chromosome 6 locus, IgK-Ef2.由6号染色体位点IgK-Ef2控制的一大组小鼠κ链。
J Exp Med. 1980 Sep 1;152(3):555-64. doi: 10.1084/jem.152.3.555.
5
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.体细胞突变在小鼠免疫球蛋白κ轻链的主要群体中产生多样性。
J Exp Med. 1984 Feb 1;159(2):417-35. doi: 10.1084/jem.159.2.417.
6
Monoclonal IgM antibody exhibiting high-affinity binding and cryoglobulin properties.表现出高亲和力结合和冷球蛋白特性的单克隆IgM抗体。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5071-4. doi: 10.1073/pnas.80.16.5071.
7
Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.编码κ链Ser亚群轻链的单个基因中的结构差异解释了两种小鼠轻链遗传标记的存在。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9134-8. doi: 10.1073/pnas.83.23.9134.
8
Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement.单个免疫球蛋白κ链等位基因的双重重组：对重排机制的影响
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4793-7. doi: 10.1073/pnas.82.14.4793.
9
Direct evidence for intrastrand DNA inversion of kappa immunoglobulin gene segments in two murine plasmacytomas.在两个小鼠浆细胞瘤中κ免疫球蛋白基因片段链内DNA倒位的直接证据。
Nucleic Acids Res. 1989 Dec 11;17(23):9797-809. doi: 10.1093/nar/17.23.9797.
10
Nucleotide sequence of the cDNAs encoding the variable region heavy and light chains of a myeloma protein specific for the terminal nonreducing end of alpha(1----6)dextran.编码对α（1→6）葡聚糖末端非还原端具有特异性的骨髓瘤蛋白重链和轻链可变区的cDNA的核苷酸序列。
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2440-3. doi: 10.1073/pnas.84.8.2440.
本文引用的文献
1
The immunoglobulins of mice. VI. Response to immunization.小鼠的免疫球蛋白。VI. 对免疫的反应。
J Immunol. 1965 Nov;95(5):781-90.
2
Biologic properties of a mouse IgG2a myeloma protein with anti-dinitrophenyl activity.具有抗二硝基苯基活性的小鼠IgG2a骨髓瘤蛋白的生物学特性。
J Immunol. 1970 Oct;105(4):812-7.
3
Construction of phylogenetic trees.系统发育树的构建。
Science. 1967 Jan 20;155(3760):279-84. doi: 10.1126/science.155.3760.279.
4
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.用于埃德曼-贝格蛋白质测序仪的定量方法。两种异常免疫球蛋白轻链Rzf和Sac的部分序列。
Biochemistry. 1971 Dec 21;10(26):4912-21. doi: 10.1021/bi00802a013.
5
Advances in the gas chromatographic analysis of amino acid phenyl- and methylthiohydantoins.氨基酸苯乙内酰脲和甲硫基乙内酰脲的气相色谱分析进展
Anal Biochem. 1972 Jan;45(1):43-59. doi: 10.1016/0003-2697(72)90006-1.
6
The immunology and pathology of NZB mice.NZB小鼠的免疫学与病理学
Adv Immunol. 1968;9:215-66. doi: 10.1016/s0065-2776(08)60444-7.
7
Mouse immunoglobulin chains. A survey of the amino-terminal sequences of kappa chains.小鼠免疫球蛋白链。κ链氨基末端序列的研究。
Biochemistry. 1973 Feb;12(4):741-9. doi: 10.1021/bi00728a026.
8
Immunoglobulin-producing tumors and myeloma proteins of mice.小鼠产生免疫球蛋白的肿瘤和骨髓瘤蛋白
Physiol Rev. 1972 Jul;52(3):631-719. doi: 10.1152/physrev.1972.52.3.631.
9
Frequency of hapten-specific B cells in neonatal and adult murine spleens.新生和成年小鼠脾脏中半抗原特异性B细胞的频率。
Eur J Immunol. 1974 Mar;4(3):155-9. doi: 10.1002/eji.1830040302.
10
Phylogenetically associated residues within the VH3 subgroup of several mammalian species. Evidence for a "pauci-gene" basis for antibody diversity.几种哺乳动物物种VH3亚组内的系统发育相关残基。抗体多样性的“少基因”基础的证据。
J Exp Med. 1973 Aug 1;138(2):410-27. doi: 10.1084/jem.138.2.410.
Zotero 插件