Fiedler W, Junker K, Schlichter A, Schubert J, Ernst G, Dahse R, Claussen U
Institute of Human Genetics and Anthropology, Department of Urology, Friedrich-Schiller-University Jena, Germany.
Kidney Int. 1999 Oct;56(4):1286-8. doi: 10.1046/j.1523-1755.1999.00689.x.
Secondary tumors are found in approximately 12 to 22% of all renal cell carcinoma, and their origin is currently unknown. To determine their potential for malignancy, we examined the telomerase activity of primary tumors and secondary lesions, and found that 86% of the lesions had an identical telomerase status as the related primary tumors, and thus probably share their malignancy potential.
在所有肾细胞癌中，约12%至22%会出现继发性肿瘤，其起源目前尚不清楚。为了确定它们的恶性潜能，我们检测了原发性肿瘤和继发性病变的端粒酶活性，发现86%的病变与相关原发性肿瘤具有相同的端粒酶状态，因此可能具有相同的恶性潜能。
