Dahse R, Fiedler W, Junker K, Schlichter A, Schubert J, Claussen U
Institute of Human Genetics, Department of Urology, University of Jena, Germany.
Kidney Int. 1999 Oct;56(4):1289-90. doi: 10.1046/j.1523-1755.1999.00688.x.
Detection of telomerase activity in renal cell carcinomas may be a key to understanding the loss of growth control in tumor cells. This enzyme forms the end of most chromosomal DNAs (that is, telomeres) found in renal tumors. When activated, the telomeres shorten with every cell cycle and then there is a compensatory lengthening of the cells, which then proliferate and eventually become immortal and metastasize. This complex multigenetic process may prove to be a useful marker of tumor progression and patient outcome.
检测肾细胞癌中的端粒酶活性可能是理解肿瘤细胞生长控制丧失的关键。这种酶形成了肾肿瘤中大多数染色体DNA的末端（即端粒）。当被激活时，端粒在每个细胞周期都会缩短，然后细胞会进行补偿性延长，接着细胞增殖并最终变得永生且发生转移。这一复杂的多基因过程可能被证明是肿瘤进展和患者预后的一个有用标志物。
