Moreau T, Loudenot V
Service de Neurologie, Hôpital de la Croix-Rousse, Lyon.
Presse Med. 1999 Sep 4;28(25):1378-80.
There is some debate concerning a possible relationship between dental fillings and multiple sclerosis. Many patients ask their dentist to remove fillings.
Dental fillings contain mercury (more than 50%) which can cross the blood-brain barrier. Massive mercurial intoxication is neurotoxic both for the central and peripheral nervous system. Dental fillings release as much mercury in 24 hours as is ingested in a normal meal, i.e. a level well under the neurotoxicity level.
Mercurial poisoning is histologically, clinically, immunologically, and toxicollogically different from multiple sclerosis. Based on data available today, it is not warranted to propose removing dental fillings.
关于补牙与多发性硬化症之间可能存在的关系存在一些争议。许多患者要求牙医去除补牙材料。
补牙材料含有汞（超过50%），汞可穿过血脑屏障。大量汞中毒对中枢神经系统和周围神经系统均具有神经毒性。补牙材料在24小时内释放的汞量与正常饮食中摄入的汞量相同，即远低于神经毒性水平。
汞中毒在组织学、临床、免疫学和毒理学方面与多发性硬化症不同。根据目前可得的数据，不建议去除补牙材料。
