Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
作者信息
Yoneda T, Mundy G R
出版信息
J Exp Med. 1979 Jan 1;149(1):279-83. doi: 10.1084/jem.149.1.279.
Abstract
The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin synthesis is necessary for OAF production.
摘要
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Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
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