前列腺素对于活化的外周血白细胞产生破骨细胞活化因子是必需的。
Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
作者信息
Yoneda T, Mundy G R
出版信息
J Exp Med. 1979 Jan 1;149(1):279-83. doi: 10.1084/jem.149.1.279.
Abstract
The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin synthesis is necessary for OAF production.
摘要
由植物血凝素刺激的正常人外周血白细胞产生破骨细胞激活因子（OAF）的过程，受到一系列结构不相关的前列腺素合成酶抑制剂的抑制。通过将E系列前列腺素重新添加到白细胞悬液中，这些试剂对OAF产生的抑制作用得以逆转。这些结果表明，前列腺素合成对于OAF的产生是必需的。
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本文引用的文献
1
BONE RESORPTION IN TISSUE CULTURE. FACTORS INFLUENCING THE RESPONSE TO PARATHYROID HORMONE.组织培养中的骨吸收。影响对甲状旁腺激素反应的因素。
J Clin Invest. 1965 Jan;44(1):103-16. doi: 10.1172/JCI105117.
2
Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes.培养的人外周血白细胞上清液中的骨吸收活性。
Science. 1972 Sep 1;177(4051):793-5. doi: 10.1126/science.177.4051.793.
3
Macrophage-lymphocyte synergy in the production of osteoclast activating factor.巨噬细胞与淋巴细胞在破骨细胞激活因子产生中的协同作用。
J Immunol. 1974 Oct;113(4):1278-87.
4
Prevention of MIF activity by agents known to increase cellular cyclic AMP.通过已知可增加细胞环磷酸腺苷（cAMP）的试剂预防巨噬细胞移动抑制因子（MIF）活性。
J Immunol. 1973 Jun;110(6):1609-14.
5
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.小鼠纤维肉瘤细胞产生的骨吸收刺激因子为前列腺素E2的证据。癌症高钙血症的一种新模型。
J Exp Med. 1972 Dec 1;136(6):1329-43. doi: 10.1084/jem.136.6.1329.
6
Prostaglandins: stimulation of bone resorption in tissue culture.前列腺素：组织培养中对骨吸收的刺激作用。
Endocrinology. 1970 Jun;86(6):1436-40. doi: 10.1210/endo-86-6-1436.
7
Drugs which inhibit prostaglandin biosynthesis.抑制前列腺素生物合成的药物。
Pharmacol Rev. 1974 Mar;26(1):33-67.
8
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9
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10
Production of osteoclast-activating factor by normal human peripheral blood rosetting and nonrosetting lymphocytes.
Eur J Immunol. 1976 Oct;6(10):732-6. doi: 10.1002/eji.1830061014.
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