Schwarzbauer J E, Sechler J L
Department of Molecular Biology Princeton University Princeton, NJ 08544-1014, USA.
Curr Opin Cell Biol. 1999 Oct;11(5):622-7. doi: 10.1016/s0955-0674(99)00017-4.
Fibronectin matrix assembly is a regulated stepwise process. In the past year, analyses of fibronectin domains, integrin and cytoskeletal contributions, and fibril architecture have provided new insights into assembly mechanisms and matrix control of cell functions. Like fibronectin, laminin polymerization is cell-mediated. Thus a common pathway for extracellular matrix assembly is emerging.
纤连蛋白基质组装是一个受调控的逐步过程。在过去的一年里，对纤连蛋白结构域、整合素和细胞骨架作用以及纤维结构的分析，为组装机制和细胞功能的基质控制提供了新的见解。与纤连蛋白一样，层粘连蛋白的聚合也是细胞介导的。因此，细胞外基质组装的共同途径正在形成。
