Streuli C
School of Biological Sciences University of Manchester 3.239 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
Curr Opin Cell Biol. 1999 Oct;11(5):634-40. doi: 10.1016/s0955-0674(99)00026-5.
The extracellular matrix is not merely a passive structure. In the past few years, it has emerged that the matrix is a dynamic action zone that functions to instruct cellular phenotype. Extracellular matrix proteins interact directly with cell surface receptors to initiate signal transduction pathways and to modulate those triggered by differentiation and growth factors. The extracellular matrix also controls the activity and presentation of a wide range of growth factors. Thus modulation of the extracellular matrix, by remodelling its structure and activity, has profound effects on its function and the consequent behaviour of cells residing on or within it.
细胞外基质并非仅仅是一个被动的结构。在过去几年中，人们逐渐认识到，该基质是一个动态的作用区域，其功能是指导细胞表型。细胞外基质蛋白直接与细胞表面受体相互作用，启动信号转导通路，并调节由分化因子和生长因子触发的信号转导通路。细胞外基质还控制着多种生长因子的活性和呈递。因此，通过重塑细胞外基质的结构和活性来对其进行调节，会对其功能以及驻留在其上或其中的细胞的后续行为产生深远影响。
