基质金属蛋白酶-1 介导的胶原降解的早期催化事件的机制。
Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1.
机构信息
Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA.
Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan, 49931, USA.
出版信息
Chemphyschem. 2023 Feb 1;24(3):e202200943. doi: 10.1002/cphc.202200943.
The front cover artwork is provided by Dr. Karabencheva-Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP-1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic zinc (II). The background shows the collagen macromolecule. Read the full text of the Research Article at 10.1002/cphc.202200649.
封面图片由密歇根理工大学的 Karabencheva-Christova 博士团队提供。图片显示了 MMP-1 与三螺旋肽（THP）形成的初始构象和催化生产构象、连接它们的自由能曲线以及催化锌（II）的配位几何。背景显示了胶原蛋白大分子。在 10.1002/cphc.202200649 上阅读研究文章的全文。
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