Kimura Tohru
Laboratory Animal Science, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1, Yoshida, Yamaguchi, 753-8515, Japan.
Lab Anim Res. 2023 Jun 9;39(1):13. doi: 10.1186/s42826-023-00165-4.
A brain abscess in human beings is a focal infection of the central nervous system frequently characterized by areas of localized cerebritis and central necrosis surrounded by a well vascularized capsule. A brain abscess, although sporadically reported, is relatively rare disease in domestic animals (horses, cattle, goats and alpacas), companion animals (dogs and cats) and laboratory nonhuman primates. Brain abscesses are life threatening disease that needs early and aggressive veterinary therapy.
The purpose of this study on a brain abscess in a Japanese monkey was to report the investigational and therapeutic processes including clinical observations, hematological and serum biochemical profiles, and magnetic resonance imaging (MRI) features, probiotic and antibiotic therapy. In clinical observation, the monkey presented with slowly progressive gentle and depressed behavioral change. Hematological findings showed that slightly declined platelet counts gradually increased in the course of the treatment. Serum biochemical profiles revealed initial markedly elevated. A series of chemotherapy provide prominent relief from the influence of the brain abscess. MRI images illustrated that a brain abscess was located in the right frontal lobe and the mass was delineated by a thick rim, indicating the capsule formation stage. The lesion chronologically decreased in size over the course of treatment. Until 11 weeks after treatment of the brain abscess, the size of brain abscess continued to reduce, leaving an organized lesion trace. To the best of my knowledge, this is the first report on successful treatment for a brain abscess in a Japanese monkey (Macaca fuscata).
Medical management of simian brain abscesses is possible based on the controlled and resolving nature of the lesions as determined by MRI and completion of a of chemical antibiotic treatment presented in this study.
人类脑脓肿是中枢神经系统的局灶性感染，其特征通常是局部脑炎性区域和中央坏死区被血管丰富的包膜所包围。脑脓肿虽然偶有报道，但在家畜（马、牛、山羊和羊驼）、伴侣动物（狗和猫）以及实验用非人灵长类动物中是相对罕见的疾病。脑脓肿是一种危及生命的疾病，需要早期积极的兽医治疗。
本项关于一只日本猕猴脑脓肿的研究目的是报告其检查和治疗过程，包括临床观察、血液学和血清生化指标以及磁共振成像（MRI）特征、益生菌和抗生素治疗。在临床观察中，这只猕猴表现出行为逐渐缓慢进展的温和及抑郁变化。血液学检查结果显示血小板计数略有下降，在治疗过程中逐渐升高。血清生化指标显示最初显著升高。一系列化疗显著减轻了脑脓肿的影响。MRI图像显示脑脓肿位于右额叶，肿块被厚壁所界定，表明处于包膜形成阶段。在治疗过程中，病变大小按时间顺序逐渐减小。直到脑脓肿治疗11周后，脑脓肿大小持续缩小，留下有组织的病变痕迹。据我所知，这是关于成功治疗日本猕猴（食蟹猴）脑脓肿的首例报告。
根据MRI确定的病变可控性和消散特性以及本研究中提出的化学抗生素治疗的完成情况，对猿猴脑脓肿进行药物治疗是可行的。
