左旋咪唑治疗复发性阿弗他口炎的随机双盲试验。

A randomized double-blind trial of levamisole in the therapy of recurrent aphthous stomatitis.

作者信息

De Cree J, Verhaegen H, De Cock W, Verbruggen F

出版信息

Oral Surg Oral Med Oral Pathol. 1978 Mar;45(3):378-84. doi: 10.1016/0030-4220(78)90523-6.

Abstract

A Controlled, double-blind study was performed to compare the effects of levamisole and placebo in eighteen patients with recurrent aphthous stomatitis. Levamisole is a drug which enhances defective cellular immune responses. It was administered in a flexible dosage schedule: 50 mg. three times daily for three consecutive days at the start of an aphthous lesion but with an interval of at least 2 weeks between courses of therapy. Placebo consisted of pills that were identical in appearance, taken according to the same schedule. Statistical evaluation showed decreased frequency of lesions, shorter duration, and diminished pain of lesions in the group receiving levamisole. Subsequent follow-up in an open trial confirmed these results.

摘要

进行了一项对照双盲研究，以比较左旋咪唑和安慰剂对18例复发性口疮性口炎患者的疗效。左旋咪唑是一种能增强缺陷细胞免疫反应的药物。其给药方案灵活：在口疮性病变开始时，每日3次，每次50毫克，连续服用3天，但疗程之间至少间隔2周。安慰剂由外观相同的药丸组成，服用时间表相同。统计评估显示，接受左旋咪唑治疗的组中病变频率降低、持续时间缩短且病变疼痛减轻。随后在开放试验中的随访证实了这些结果。