Miller M F, Silvert M E, Laster L L, Green P, Ship I I
J Oral Pathol. 1978;7(6):387-92. doi: 10.1111/j.1600-0714.1978.tb01607.x.
Twenty patients with severe recurrent aphthous stomatitis were treated with a new drug, levamisole, to determine its effects upon the incidence and prevalence of recurrent aphthous stomatitis. The trial, conducted in a non-crossover, double-blind fashion, did not demonstrate any statistically significant differences when levamisole and placebo groups were compared over time either in the number of ulcers, number of ulcer-days, mean duration of ulcers, or mean number of ulcers per day. Positive subjective results were experienced by the 10 patients receiving levamisole but these were not of sufficient magnitude to affect group mean differences.
20名患有严重复发性口疮性口炎的患者接受了一种新药左旋咪唑的治疗，以确定其对复发性口疮性口炎发病率和患病率的影响。该试验采用非交叉、双盲方式进行，在比较左旋咪唑组和安慰剂组随时间变化时，无论是溃疡数量、溃疡天数、溃疡平均持续时间还是每日平均溃疡数量，均未显示出任何具有统计学意义的差异。接受左旋咪唑治疗的10名患者有积极的主观结果，但这些结果的程度不足以影响组间均值差异。
