Gervil M, Ulrich V, Kyvik K O, Olesen J, Russell M B
Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
Ann Neurol. 1999 Oct;46(4):606-11. doi: 10.1002/1531-8249(199910)46:4<606::aid-ana8>3.0.co;2-o.
To investigate the importance of genetic and environmental factors to the etiology of migraine without aura and to compare the symptomatology of migraine without aura in monozygotic and dizygotic twins, 2,680 twin pairs were recruited from the population-based Danish Twin Registry. Monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs, where at least one twin had self-reported migraine or self-reported severe headache with accompanying symptoms, were telephone interviewed by a physician. The participation rate in the telephone interview was 90%. The pairwise concordance rate was significantly higher in MZ than in DZ twin pairs (28% vs 18%). The probandwise concordance rate was 40% (95% CI, 33-48%) in MZ and 28% (95% CI, 23-33%) in DZ twin pairs. The pairwise concordance rates for the different pain characteristics and accompanying symptoms were not significantly different in MZ and DZ twin pairs. However, comparing all of the pairwise concordance rates of pain characteristics and accompanying symptoms together, MZ twin pairs were significantly more concordant than DZ twin pairs. Our data demonstrate a significant genetic factor in migraine without aura. The size of this factor is modest and the demonstration of susceptibility genes is predicted to be laborious and difficult.
为了研究遗传和环境因素在无先兆偏头痛病因学中的重要性，并比较单卵双胞胎和双卵双胞胎中无先兆偏头痛的症状学，我们从基于人群的丹麦双胞胎登记处招募了2680对双胞胎。对于至少有一名双胞胎自我报告患有偏头痛或自我报告伴有相关症状的严重头痛的单卵（MZ）和同性双卵（DZ）双胞胎对，由一名医生进行电话访谈。电话访谈的参与率为90%。MZ双胞胎对的成对一致性率显著高于DZ双胞胎对（28%对18%）。在MZ双胞胎对中，先证者一致性率为40%（95%CI，33 - 48%），在DZ双胞胎对中为28%（95%CI，23 - 33%）。MZ和DZ双胞胎对中不同疼痛特征及伴随症状的成对一致性率无显著差异。然而，将所有疼痛特征和伴随症状的成对一致性率综合比较，MZ双胞胎对比DZ双胞胎对的一致性显著更高。我们的数据表明无先兆偏头痛存在显著的遗传因素。该因素的影响程度适中，预计寻找易感基因将既费力又困难。
