Gonzalez-Villalpando C, Blachley J D, Vaughan G M, Smith J D
JAMA. 1979 Mar 2;241(9):925-7.
We compared low-dose, continuous insulin infusion with a conventional high-dose intravenous bolus method of insulin administration in 18 episodes of diabetic ketoacidosis. The average rate of reduction in serum glucose concentration was 9.5 +/- 3.8%/hr in the continuous infusion group and 10.7 +/- 4.7%/hr in the bolus group. Arterial blood pH was corrected to 7.35 by 9.9 +/- 2.6/hours in the continuous infusion group and by 10.4 +/- 3.2/hours in the bolus group. The above means are not significantly different between groups. By the time pH was corrected to 7.35, patients in the continuous infusion group had received 121 +/- 44 units of insulin, whereas those in the bolus group had received 326 +/- 152 units. The continuous low-dose insulin infusion method is as safe and efficacious as the conventional high-dose intravenous bolus method.
我们在18例糖尿病酮症酸中毒病例中，比较了小剂量持续胰岛素输注与传统大剂量静脉推注胰岛素给药方法。持续输注组血清葡萄糖浓度平均降低速率为9.5±3.8%/小时，推注组为10.7±4.7%/小时。持续输注组动脉血pH值在9.9±2.6小时校正至7.35，推注组在10.4±3.2小时校正至7.35。上述均值在两组间无显著差异。当pH值校正至7.35时，持续输注组患者接受了121±44单位胰岛素，而推注组患者接受了326±152单位胰岛素。小剂量持续胰岛素输注方法与传统大剂量静脉推注方法一样安全有效。
