Fond L, Michel J L, Gentil-Perret A, Montelimard N, Perrot J L, Chalencon V, Cambazard F
Service de dermatologie, Hôpital Nord, CHU de Saint-Etienne, France.
Arch Pediatr. 1999 Sep;6(9):1017-21. doi: 10.1016/s0929-693x(99)80599-5.
Granuloma annulare is a benign, common, inflammatory skin lesion of unknown etiology that is seen in both adults and children. The typical lesions are single or multiple small cutaneous papules with an annular distribution. The histology is consistent with an area of fibrinoid degeneration of collagen, surrounded by palisading histiocytes and inflammatory cells. There are four clinically distinct subtypes: localized, generalized, subcutaneous and perforating. Usually a spontaneous resolution is expected. Many medical treatments have been proposed but without evidence of efficacy. The association with insulin dependent diabetes is still being discussed.
环状肉芽肿是一种病因不明的良性、常见的炎症性皮肤病变，可见于成人和儿童。典型病变为单个或多个呈环状分布的小皮肤丘疹。组织学表现为胶原纤维蛋白样变性区域，周围有栅栏状组织细胞和炎症细胞。临床上有四种不同亚型：局限性、泛发性、皮下型和穿通型。通常预计会自发消退。已提出许多医学治疗方法，但均无疗效证据。与胰岛素依赖型糖尿病的关联仍在讨论中。
