Juaristi E, López-Ruiz H
Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, México, 07000 D.F., México.
Curr Med Chem. 1999 Oct;6(10):983-1004.
The introductory section of this review presents some of the currently most compelling beta-amino acid targets, according to their structural types: alpha- and beta-aryl substituted, olefinic and alkynyl, alpha, alpha- and alpha,beta-disubstituted, cyclic and conformationally restricted, fluorine-containing, and phosphonic analogous beta-amino acids. The main section highlights some of the very new (1996-1998), promising methodology for the enantioselective synthesis of beta-amino acids, with especial emphasis on catalytic and enzymatic processes, as well as methods based on "chiral pool", self-regeneration of stereogenic centers , diastereoselective nucleophilic additions to prochiral double bonds, and enantioselective reactions in the presence of chiral additives.
本综述的引言部分根据其结构类型介绍了一些目前最具吸引力的β-氨基酸靶点：α-和β-芳基取代的、烯基和炔基的、α,α-和α,β-二取代的、环状和构象受限的、含氟的以及膦酸类似物β-氨基酸。主要部分重点介绍了一些非常新的（1996 - 1998年）、有前景的对映选择性合成β-氨基酸的方法，特别强调催化和酶促过程，以及基于“手性库”、立体中心的自再生、前手性双键的非对映选择性亲核加成和在手性添加剂存在下的对映选择性反应的方法。
