奥利斯特拉会增加2,3,7,8-四氯二苯并对二恶英的粪便排泄量。
Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
作者信息
Geusau A, Tschachler E, Meixner M, Sandermann S, Päpke O, Wolf C, Valic E, Stingl G, McLachlan M
出版信息
Lancet. 1999 Oct 9;354(9186):1266-7. doi: 10.1016/S0140-6736(99)04271-3.
Abstract
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.
摘要
两名患氯痤疮的患者血液脂质中2,3,7,8 - 四氯二苯并 - 对 - 二恶英（TCDD）的浓度分别为144,000和26,000皮克/克。奥利司他，一种不可消化的亲脂性膳食脂肪替代品，使患者肠道对TCDD的排泄加快了八到十倍。这足以将通常观察到的TCDD消除半衰期从约7年缩短至1 - 2年。
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