Neuberger M, Landvoigt W, Derntl F
Department of Preventive Medicine, University of Vienna, Austria.
Int Arch Occup Environ Health. 1991;63(5):325-7. doi: 10.1007/BF00381582.
Nine production workers with a history of chloracne from exposure to polychlorinated dibenzo-p-dioxins (PCDDs) in 1971-1973 had a median level of 340 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) per gram blood lipid (range 98-659 pg/g) in 1990. This was significantly higher than blood levels in 4 reference subjects without chloracne and no known exposure from the same plant (median 18, range 8-28 pg/g) and in 17 external referents (median 16, range less than 5-23 pg/g). We therefore consider chloracne to be a reliable indicator of heavy dioxin exposure in a cohort of herbicide production workers and will use its former presence in 159 cases as a substitute for exposure when investigating cancer morbidity and mortality in a multicenter cohort study.
1971年至1973年间，9名曾因接触多氯二苯并对二恶英（PCDDs）而患氯痤疮的生产工人，在1990年时每克血脂中2,3,7,8-四氯二苯并对二恶英（TCDD）的含量中位数为340皮克（范围为98 - 659皮克/克）。这显著高于来自同一工厂的4名无氯痤疮且无已知接触史的对照对象的血中水平（中位数为18皮克，范围为8 - 28皮克/克）以及17名外部对照对象的血中水平（中位数为16皮克，范围小于5 - 23皮克/克）。因此，我们认为氯痤疮是除草剂生产工人群体中重度二恶英接触的可靠指标，并且在一项多中心队列研究中调查癌症发病率和死亡率时，将在159例病例中曾患氯痤疮作为接触的替代指标。
