Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
Environ Pollut. 2019 Dec;255(Pt 1):113210. doi: 10.1016/j.envpol.2019.113210. Epub 2019 Sep 7.
Polychlorinated biphenyls (PCBs) have been detected as prevalent environmental contaminants in water, food and biota. Previous studies in vitro have shown that a variety of sorbent materials, including carbon, can sorb PCBs; however, PCB sorbents that can be added to food or drinking water to decrease toxin bioavailability in humans and animals have not been reported. To address this problem, we have developed broad-acting and highly effective sorbents for PCBs using montmorillonite clays reported to be safe for consumption in animals and humans. In this study, calcium montmorillonite clays were acid processed (APMs) and the interactions of six PCB congeners (PCB 77, 126, 153, 157, 154 and 155) on the surfaces of APMs were characterized. Computational models and isothermal analyses were used to derive surface capacities and affinities, delineate mechanisms and predict the thermodynamics of sorption. To confirm the safety and predict the efficacy of APMs against individual PCBs and common mixtures (Aroclors 1254 and 1260), we have also used a living organism (Hydra vulgaris) that is sensitive to toxins. APMs significantly protected hydra against the toxicity of PCBs and Aroclors. This finding was supported by studies showing tight binding; high capacity, affinity, and enthalpy; and a low therapeutic dose.
多氯联苯（PCBs）已被检测为水中、食物中和生物群中的普遍存在的环境污染物。先前的体外研究表明，包括碳在内的各种吸附材料都可以吸附 PCBs；然而，尚未有报道称可以将 PCB 吸附剂添加到食物或饮用水中以降低人类和动物体内毒素的生物利用度。为了解决这个问题，我们使用据报道可安全用于动物和人类的蒙脱石粘土开发了广谱且高效的 PCB 吸附剂。在这项研究中，对钙蒙脱石粘土进行了酸处理（APM），并对六种 PCB 同系物（PCB 77、126、153、157、154 和 155）在 APM 表面的相互作用进行了表征。计算模型和等温分析用于得出表面容量和亲和力，描绘机制并预测吸附的热力学。为了确认 APM 的安全性并预测其对个别 PCB 和常见混合物（Aroclors 1254 和 1260）的功效，我们还使用了对毒素敏感的生物体（Hydra vulgaris）。APM 显著保护水螅免受 PCB 和 Aroclors 的毒性影响。这一发现得到了研究的支持，这些研究表明结合紧密、高容量、亲和力和焓，以及低治疗剂量。
