Black A R, Azizkhan-Clifford J
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Gene. 1999 Sep 17;237(2):281-302. doi: 10.1016/s0378-1119(99)00305-4.
Members of the E2F family of transcription factors are key participants in orchestration of the cell cycle, cell growth arrest and apoptosis. Therefore, an understanding of the regulation of E2F activity is essential for an understanding of the control of cellular proliferation. E2F activity is regulated by the retinoblastoma family of tumor suppressors and by multiple other mechanisms. This review will describe our current knowledge of these mechanisms which together constitute a highly complex network by which the cell cycle and cellular proliferation can be controlled.
转录因子E2F家族成员是细胞周期、细胞生长停滞和细胞凋亡调控中的关键参与者。因此，了解E2F活性的调控对于理解细胞增殖的控制至关重要。E2F活性受视网膜母细胞瘤肿瘤抑制因子家族及多种其他机制的调控。本综述将阐述我们目前对这些机制的认识，这些机制共同构成了一个高度复杂的网络，通过该网络可对细胞周期和细胞增殖进行调控。
