Bobele G B
Department of Pediatric Neurology, Driscoll Children's Hospital, Corpus Christi, TX, USA.
Semin Pediatr Neurol. 1999 Sep;6(3):168-71; discussion 171-2. doi: 10.1016/s1071-9091(99)80008-4.
A 5-year-old boy presented with an acute ataxia and altered mental status. Although he initially recovered from these symptoms, he presented a second time with myoclonus and seizures and rapidly became vegetative. Cerebrospinal fluid studies, magnetic resonance imaging, and brain biopsy all confirmed the presence of subacute sclerosing panencephalitis. Despite courses of therapy with cimetidine, amantadine, ribavirin, and inosine, no clinical improvement has been seen. Clinicians need to be alert to the possibility of subacute sclerosing panencephalitis even in the vaccinated child in the appropriate clinical setting.
一名5岁男孩出现急性共济失调和精神状态改变。尽管他最初从这些症状中恢复过来，但第二次出现肌阵挛和癫痫发作，并迅速进入植物人状态。脑脊液检查、磁共振成像和脑活检均证实存在亚急性硬化性全脑炎。尽管使用西咪替丁、金刚烷胺、利巴韦林和肌苷进行了疗程治疗，但未见临床改善。即使在适当临床环境下接种过疫苗的儿童中，临床医生也需要警惕亚急性硬化性全脑炎的可能性。
