Dlugos D J, Brooks-Kayal A R
Children's Hospital of Philadelphia, PA 19104, USA.
Semin Pediatr Neurol. 1999 Sep;6(3):164-7. doi: 10.1016/s1071-9091(99)80007-2.
This article reports a typical case of subacute sclerosing panencephalitis (SSPE). The patient contracted measles as an infant during the 1989 to 1991 United States measles epidemic. At 4 1/2 years of age, he developed behavioral changes and quickly progressed through the typical clinical stages of SSPE. His EEG was characteristic. Serum and CSF measles immunoglobulin G were markedly elevated. He remains alive but is vegetative. To our knowledge, this is the first case of SSPE stemming from the 1989 to 1991 measles epidemic. Because infants--the group at highest risk to develop SSPE--were most severely affected by this measles outbreak, other cases of SSPE stemming from this epidemic may occur.
本文报告了一例亚急性硬化性全脑炎（SSPE）的典型病例。该患者在1989年至1991年美国麻疹流行期间还是婴儿时感染了麻疹。4岁半时，他出现行为改变，并迅速经历了SSPE的典型临床阶段。他的脑电图具有特征性。血清和脑脊液中的麻疹免疫球蛋白G显著升高。他仍然活着，但呈植物人状态。据我们所知，这是首例源于1989年至1991年麻疹流行的SSPE病例。由于婴儿——发生SSPE风险最高的群体——在这次麻疹疫情中受影响最为严重，可能还会出现源于这次疫情的其他SSPE病例。
