Kennedy D N, O'Craven K M, Ticho B S, Goldstein A M, Makris N, Henson J W
Center for Morphometric Analysis, Massachusetts General Hospital, Boston, USA.
Neurology. 1999 Oct 12;53(6):1260-5. doi: 10.1212/wnl.53.6.1260.
To determine whether individuals with situs inversus totalis (SI), a condition in which there is a mirror-image reversal of asymmetric visceral organs, have alterations in brain asymmetries.
The human brain is asymmetric in structure and function. Although correlations between anatomic asymmetries and functional lateralization in human brain have been demonstrated, it has been difficult to further analyze them. Characterization of asymmetries of brain structure and function in SI might advance the understanding of these relationships.
Using anatomic and functional MRI techniques, we analyzed asymmetries in the brains of three individuals with SI.
Two major anatomic asymmetries of the cerebral hemispheres, the frontal and occipital petalia, were reversed in individuals with SI. In contrast, SI subjects had left cerebral hemisphere language dominance on functional MRI analysis as well as strong right-handedness.
These observations suggest that the developmental factors determining anatomic asymmetry of the cerebral petalia and viscera are distinct from those producing the functional lateralization of language.
确定完全性内脏反位（SI）个体（一种非对称内脏器官呈镜像反转的病症）的脑不对称性是否存在改变。
人类大脑在结构和功能上是不对称的。尽管已证实人类大脑解剖学不对称与功能偏侧化之间存在相关性，但进一步分析它们一直很困难。对SI患者脑结构和功能不对称性的特征描述可能会促进对这些关系的理解。
我们使用解剖学和功能性磁共振成像技术，分析了三名SI个体的大脑不对称性。
SI个体大脑半球的两个主要解剖学不对称，即额叶和枕叶脑岛，发生了反转。相比之下，在功能性磁共振成像分析中，SI受试者的左脑半球具有语言优势，并且表现出强烈的右利手倾向。
这些观察结果表明，决定脑岛和内脏解剖学不对称性的发育因素与产生语言功能偏侧化的因素不同。
