Ferrando J, Grimalt R
Department of Dermatology, Hospital Clínic, University of Barcelona, Villarroel 170, 08036 Barcelona Spain.
Eur J Dermatol. 1999 Oct-Nov;9(7):544-7.
We report 6 adolescent females apparently affected by diffuse partial woolly hair. The patients complained of thinning and curling of some hair of the scalp. Examination revealed two distinct hair populations. The first hair population was straight, normally pigmented and of normal length, thus considered "normal" hair. The second hair population was wavy, curly, thinner and apparently slightly shorter, thus considered abnormal. Direct examination of the abnormal hair population under a light microscope revealed a curled pattern of the hair shaft, and single torsions. With light microscopy the clinically normal hair had no abnormalities. Under scanning electron microscopy (SEM) the abnormal hair had curly and flattened hair shafts of 30-60 mum in diameter, oval shaped sections, canalicular formations, single torsions and cuticular weathering. With SEM, clinically "normal" hair had a diameter between 60-80 mum, with no major relevant abnormalities except for weathering. These results are suggestive of a new variant of acquired kinking (curling) of hair simulating diffuse partial woolly hair. The absence of clinical alterations in the proximal area of the affected hair and the spontaneous improvement with time, suggests that this variant may result from environmental exposure (weathering, cosmetic procedures) in predisposed individuals.
我们报告了6名明显患有弥漫性部分羊毛状毛发的青春期女性。患者主诉头皮部分毛发稀疏和卷曲。检查发现两种不同的毛发群体。第一种毛发群体是直的，色素沉着正常且长度正常，因此被认为是“正常”毛发。第二种毛发群体是波浪状、卷曲状、更细且明显稍短，因此被认为是异常毛发。在光学显微镜下直接检查异常毛发群体发现毛干呈卷曲状且有单扭转。光学显微镜下临床正常的毛发无异常。在扫描电子显微镜（SEM）下，异常毛发的毛干卷曲且扁平，直径为30 - 60微米，呈椭圆形截面，有管状结构、单扭转和角质层风化。通过SEM观察，临床“正常”毛发直径在60 - 80微米之间，除了风化外无主要相关异常。这些结果提示一种模拟弥漫性部分羊毛状毛发的获得性毛发扭结（卷曲）新变体。受累毛发近端区域无临床改变且随时间自发改善，提示该变体可能是由易感个体的环境暴露（风化、美容程序）导致的。
