Lalević-Vasić B M, Nikolić M M, Polić D J, Radosavljević B
Department of Dermatology, University Clinical Centre, Belgrade, Serbia.
Dermatology. 1993;187(4):243-7. doi: 10.1159/000247257.
We report 4 new cases presenting with the characteristics of a recently described pilar dysplasia entitled 'diffuse partial woolly hair'. Two of our cases were familial (mother and daughter), while the 2 other were sporadic. Scalp hair of all the patients exhibited two hair shaft populations intermingled throughout the scalp. The first hair type was straight, normally pigmented and of normal length, while the second type was wavy and the shafts were hypopigmented, thinner, shorter and easily pluckable. One of our patients presented with a diffuse hair thinning due to a progressive loss of wavy hairs. Under reflected light, both hair populations displayed alternating dark and bright segments. Scanning-electron microscopic analysis of straight and wavy hairs revealed comparable lesions: torsions, angular kinks, weathering as well as grooved segments alternating with the normal ones. These changes were the most severely expressed in the shortest and the waviest hairs. Taken together, the clinical and microscopic characteristics of this pilar dysplasia justify its introduction as a separate entity into the woolly hair group.
我们报告了4例具有最近描述的一种名为“弥漫性部分羊毛状发”的毛发发育异常特征的新病例。我们的病例中有2例为家族性（母亲和女儿），另外2例为散发性。所有患者头皮毛发均表现为两种毛干群体在整个头皮上相互交织。第一种毛发类型是直的，色素正常且长度正常，而第二种毛发类型是波浪状的，毛干色素减退、更细、更短且容易拔除。我们的一名患者因波浪状毛发逐渐脱落而出现弥漫性头发稀疏。在反射光下，两种毛发群体均显示出明暗交替的节段。对直发和波浪状毛发进行扫描电子显微镜分析发现了类似的病变：扭转、角状扭结、风化以及与正常节段交替出现的沟状节段。这些变化在最短和最波浪状的毛发中表现最为严重。综上所述，这种毛发发育异常的临床和显微镜特征证明将其作为一个独立实体引入羊毛状发组是合理的。
