Groves M J, Martinian L, An S F, Scaravilli F
Department of Neurophatology, Institute of Neurology, London, UK.
J Anat. 1999 Aug;195 ( Pt 2)(Pt 2):271-80. doi: 10.1046/j.1469-7580.1999.19520271.x.
Adult dorsal root ganglion neurons express oligosaccharides conjugated to lipids that may be involved in cell-cell recognition, and consequently in the laminar organisation of their central terminations. This paper describes an immunohistochemical study of the developmental expression of 2 lactoseries (LA4 and LD2) and 1 globoseries (SSEA4) oligosaccharide conjugates in rats from embryonic d 19 to postnatal d 60. The expression of calcitonin gene related peptide and the growth associated protein GAP43 was also examined for comparative purposes. We found that these oligosaccharide conjugates begin to be expressed after birth, suggesting that they may be involved in maturation of the central or peripheral terminations, rather than axonal guidance.
成年背根神经节神经元表达与脂质结合的寡糖，这些寡糖可能参与细胞间识别，并因此参与其中心终末的层状组织。本文描述了对大鼠从胚胎第19天到出生后第60天2种乳糖系列（LA4和LD2）和1种球系列（SSEA4）寡糖缀合物发育表达的免疫组织化学研究。为了进行比较，还检测了降钙素基因相关肽和生长相关蛋白GAP43的表达。我们发现这些寡糖缀合物在出生后开始表达，这表明它们可能参与中枢或外周终末的成熟，而非轴突导向。
