Takahashi Norimasa, Wada Yuichi, Ohtori Seiji, Saisu Takashi, Moriya Hideshige
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.
Auton Neurosci. 2003 Sep 30;107(2):81-4. doi: 10.1016/S1566-0702(03)00134-6.
There have been several reports on the use of extracorporeal shock waves in the treatment of pseudarthrosis, calcifying tendinitis, and tendinopathies of the elbow. However, the pathomechanism of pain relief has not been clarified. To investigate the analgesic properties of shock wave application, we analyzed changes in calcitonin gene-related peptide (CGRP)-immunoreactive (ir) dorsal root ganglion (DRG) neurons. In the nontreated group, fluorogold-labeled dorsal root ganglion neurons innervating the most middle foot pad of hind paw were distributed in the L4 and L5 dorsal root ganglia. Of these neurons, 61% were CGRP-ir. However, in the shock wave-treated group, the percentage of FG-labeled CGRP-ir DRG neurons decreased to 18%. These data show that relief of clinical pain after shock wave application may result from reduced CGRP expression in DRG neurons.
关于体外冲击波用于治疗假关节、钙化性肌腱炎和肘部肌腱病已有多篇报道。然而，疼痛缓解的病理机制尚未阐明。为了研究冲击波应用的镇痛特性，我们分析了降钙素基因相关肽（CGRP）免疫反应性（ir）背根神经节（DRG）神经元的变化。在未治疗组中，支配后爪最中间脚垫的荧光金标记背根神经节神经元分布在L4和L5背根神经节中。在这些神经元中，61%为CGRP-ir。然而，在冲击波治疗组中，FG标记的CGRP-ir DRG神经元的百分比降至18%。这些数据表明，冲击波应用后临床疼痛的缓解可能是由于DRG神经元中CGRP表达降低所致。
