Barta E, Kuzela L, Kvetnanský R, Siska K, Babusíková F, Torda T
Z Exp Chir. 1975;8(6):379-83.
On the model of anoxic cardioplegia in cardiosurgical patients the influence of anoxia on the activity of monoamine oxidase (MAO) and catechol-O-methyltransferase (COMPT) in right auricular tissue was studied. It was found out that the activity of COMT does not change during anoxia, the activity of MAO considerably increases. With regard to catecholamines stimulating effect upon cardiac metabolism as well as to their calorigenic and oxygen wasting effect the raise of MAO activity may be regarded as favourable phenomenon, because the hastened degradation of released catecholamines at least to a certain degree diminishes the disproportion between oxygen supply and actual oxygen need of the heart and by means of that mitigates the anoxic damage of myocardium.
在心脏外科手术患者的缺氧心脏停搏模型上，研究了缺氧对右心耳组织中单胺氧化酶（MAO）和儿茶酚 - O - 甲基转移酶（COMPT）活性的影响。结果发现，缺氧期间COMT的活性没有变化，而MAO的活性显著增加。鉴于儿茶酚胺对心脏代谢的刺激作用及其产热和耗氧作用，MAO活性的升高可被视为有利现象，因为释放的儿茶酚胺加速降解至少在一定程度上减少了心脏氧气供应与实际氧气需求之间的不平衡，从而减轻了心肌的缺氧损伤。
