成年女性双胞胎心血管疾病风险因素聚集的遗传分析。

A genetic analysis of cardiovascular disease risk factor clustering in adult female twins.

作者信息

Mosteller M

机构信息

Department of Human Genetics, Virginia Commonwealth University, Richmond.

出版信息

Genet Epidemiol. 1993;10(6):569-74. doi: 10.1002/gepi.1370100640.

DOI:10.1002/gepi.1370100640

PMID:8314062

Abstract

Risk factors for cardiovascular disease have been shown to cluster in adult populations of men and women [Criqui et al., 1980]. In a population of adult female twin pairs (ages 18-85), body mass index, systolic and diastolic blood pressure, and high and low density lipoprotein levels were found to exhibit significant clustering. Path analysis was used to resolve the risk factor correlations into genetic, environmental, and age-related components.

摘要

心血管疾病的风险因素已被证明在成年男性和女性人群中聚集[克里奎等人，1980年]。在成年女性双胞胎对（年龄18 - 85岁）群体中，发现体重指数、收缩压和舒张压以及高密度和低密度脂蛋白水平存在显著聚集现象。路径分析被用于将风险因素相关性分解为遗传、环境和与年龄相关的成分。