VON Hunolstein Christina, Parisi Laura, Tissi Luciana, Recchia Simona, Alfarone Giovanna, Nicolini Laura, Volpe Corrado, Wagner Barbara, Motlova Jitka, Orefici Graziella
Laboratorio di Batteriologia e Micologia Medica, Rome, Italy.
Servizio Biologico, Istituto Superiore di Sanità, Rome, Italy.
J Med Microbiol. 1999 Nov;48(11):983-990. doi: 10.1099/00222615-48-11-983.
Strains of a new polysaccharide type of group B streptococci (GBS), type VII, have been isolated from human carriers and invasive infections. Some of these strains bear the protein antigen c or R, as do other GBS serotypes. The capsular type polysaccharide is sialylated and this residue is involved in the immunodeterminant structure. All type VII strains examined were virulent in CD-1 mice; the LD50 after intraperitoneal (i.p.) challenge was 4.57 (SD 0.12) x10(7) cfu for the reference strain and 5.49 (SD 1.5) x10(7) cfu for clinical isolates. A particular feature of this serotype was the ability to induce septic arthritis not only when injected intravenously (i.v.), but also when injected i.p. Rabbit antiserum against the capsular type VII polysaccharide exhibited opsonic activity in a phagocytosis assay and protective activity against infection.
已从人类携带者和侵袭性感染中分离出一种新型的B族链球菌（GBS）多糖菌株，即VII型。其中一些菌株携带蛋白质抗原c或R，其他GBS血清型也是如此。荚膜型多糖被唾液酸化，且该残基参与免疫决定结构。所有检测的VII型菌株在CD-1小鼠中均具有毒性；参考菌株经腹腔注射（i.p.）攻击后的半数致死量（LD50）为4.57（标准差0.12）×10⁷ cfu，临床分离株为5.49（标准差1.5）×10⁷ cfu。该血清型的一个特殊特征是不仅静脉注射（i.v.）时能诱发败血症性关节炎，腹腔注射时也能诱发。兔抗VII型荚膜多糖抗血清在吞噬试验中表现出调理活性，并对感染具有保护活性。
