Abrahams S, Morris R G, Polkey C E, Jarosz J M, Cox T C, Graves M, Pickering A
Department of Psychology, Institute of Psychiatry, London, United Kingdom.
Brain Cogn. 1999 Oct;41(1):39-65. doi: 10.1006/brcg.1999.1095.
Forty-seven patients with unilateral temporal lobe epilepsy (TLE) were investigated on the Nine-Box Maze. The task was designed to compare working memory and spatial mapping theories of the functions of the hippocampus and provide measures of spatial, object, working, and reference memory. The results extended our previous findings in a larger group of patients. Spatial memory deficits across both working and reference memory conditions were found in patients with a right epileptogenic focus. There was no evidence of an object working memory deficit, but a nonlateralized impairment in object reference memory was revealed, which is consistent with our previous findings. The pattern of results was confirmed in a subgroup of 33 patients with unilateral atrophy localized to the hippocampus and parahippocampal gyrus, as verified by volumetric analysis of magnetic resonance images. In addition spatial memory errors significantly correlated with volumetric measures of mesial temporal lobe structures and not with measures of the remaining temporal cortex. In contrast, object reference memory errors correlated with volumetric measures of the temporal cortex and not with mesial temporal lobe structures. These findings support a specialized role for the right hippocampal region in spatial memory.
47名单侧颞叶癫痫（TLE）患者接受了九格迷宫测试。该任务旨在比较海马体功能的工作记忆和空间映射理论，并提供空间、物体、工作和参照记忆的测量方法。结果扩展了我们之前在更大患者群体中的发现。在右侧致痫灶患者中发现了工作记忆和参照记忆条件下的空间记忆缺陷。没有证据表明存在物体工作记忆缺陷，但发现了物体参照记忆的非单侧性损伤，这与我们之前的发现一致。通过磁共振图像的体积分析证实，在33名单侧海马体和海马旁回萎缩的患者亚组中，结果模式得到了证实。此外，空间记忆错误与内侧颞叶结构的体积测量显著相关，而与其余颞叶皮质的测量无关。相比之下，物体参照记忆错误与颞叶皮质的体积测量相关，而与内侧颞叶结构无关。这些发现支持右侧海马区在空间记忆中具有特殊作用。
