Glant T, Hadas E, Nagy M
Scand J Immunol. 1979;9(1):39-44. doi: 10.1111/j.1365-3083.1979.tb02704.x.
Cell-mediated immunity and antibody production to cartilage antigens were studied in rabbits. From day 3 of immunization an inhibition of leucocyte migration was observed in animals immunized with collagen-free fractions of bovine nasal or human rib cartilage. Delayed cutaneous hypersensitivity was elicited between 5 and 6 days and the circulating antibodies were demonstrated by passive haemagglutination on day 9. No significant correlation was observed between the antibody production and the cell-mediated immunity. Cell-mediated immune responses to cartilage antigens and to purified protein derivative were distinctly different, but the two antigens influenced one another when they were administered together. The 'species common' antigen of connective tissues may be primarily responsible for the early immune reactions.
在兔子身上研究了针对软骨抗原的细胞介导免疫和抗体产生情况。从免疫第3天起，在用牛鼻或人肋软骨的无胶原蛋白组分免疫的动物中观察到白细胞迁移受到抑制。在第5至6天引发了迟发型皮肤超敏反应，并在第9天通过被动血凝反应证实了循环抗体的存在。未观察到抗体产生与细胞介导免疫之间存在显著相关性。对软骨抗原和纯化蛋白衍生物的细胞介导免疫反应明显不同，但当两种抗原一起给药时，它们会相互影响。结缔组织的“种属共同”抗原可能是早期免疫反应的主要原因。
