Jose P E, Kullu P, David J, Kulkarni C
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Pol J Pharmacol. 1999 Jul-Aug;51(4):357-61.
The time course of appearance of 'wet dot shakes' (WDS) was examined following valproic acid (VPA, 100, 200, 300, 400 mg/kg i.p.) and aminophylline (AMP, 50, 100, 150 mg/kg i.p.) injections. VPA and AMP at various doses showed a qualitative difference in their ability to induce WDS with no difference in intensity, confirming 'all or none' nature of the phenomenon. There was a significant (p<0.001), dose-dependent increase in the number of whole body shakes following first three doses of VPA but not after the administration of its highest dose (400 mg/kg). In contrast, the numbers of WDS produced by AMP were inversely proportional to its increasing doses. The maximum numbers of WDS were observed at 300 mg/kg of VPA and 50 mg/kg of AMP, within 10 min and 20-30 min during 1 h and 1 h 30 min observation period, respectively. The present stereotyped behavior induced by acute, single dose administration of VPA and AMP in non-toxic doses, being a reproducible phenomenon, lasting for a brief period may be anticipated to serve as a tool to explore mechanisms underlying WDS.
在腹腔注射丙戊酸（VPA，100、200、300、400mg/kg）和氨茶碱（AMP，50、100、150mg/kg）后，研究了“湿点抖动”（WDS）出现的时间进程。不同剂量的VPA和AMP在诱导WDS的能力上表现出质的差异，强度无差异，证实了该现象的“全或无”性质。在前三个剂量的VPA给药后，全身抖动的次数有显著（p<0.001）的剂量依赖性增加，但在给予其最高剂量（400mg/kg）后则没有。相比之下，AMP产生的WDS数量与其剂量增加成反比。在1小时和1小时30分钟的观察期内，分别在10分钟内和20 - 30分钟内，在300mg/kg的VPA和50mg/kg的AMP时观察到WDS的最大数量。急性单次给予无毒剂量的VPA和AMP所诱导的这种刻板行为是一种可重复的现象，持续时间较短，有望作为探索WDS潜在机制的一种工具。
