Sieklucka-Dziuba M, Kleinrok Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):119-28.
The influence of antiepileptic drugs on the wet dog shakes (WDS) induced by intracerebroventricular injections of carbachol (30 micrograms icv) was investigated in rats. Diphenylhydantoin (DPH, 8 and 4 mg/kg), diazepam (0.4, 0.2 and 0.1 mg/kg), phenobarbital (12.5, 6.25 and 3.12 mg/kg), sodium valproate (Depakine, 200, 100 and 50 mg/kg) and trimethadione (200, 100 and 50 mg/kg) given ip inhibited the WDS in a dose-dependent manner. These drugs at the same doses did not change the intensity of shaking behavior induced by lithium chloride or 5-hydroxytryptamine. As the antiepileptic drugs tested in these experiments did not have anticholinergic activity and at used doses were not able to prevent electrical convulsions or pentetrazol-induced seizures, it appears that carbachol-induced WDS could be connected with convulsive activity and could be the initial stage of seizures.
在大鼠中研究了抗癫痫药物对脑室内注射卡巴胆碱（30微克脑室内注射）诱导的湿狗颤抖（WDS）的影响。腹腔注射苯妥英（DPH，8和4毫克/千克）、地西泮（0.4、0.2和0.1毫克/千克）、苯巴比妥（12.5、6.25和3.12毫克/千克）、丙戊酸钠（德巴金，200、100和50毫克/千克）和三甲双酮（200、100和50毫克/千克）以剂量依赖性方式抑制WDS。相同剂量的这些药物不会改变氯化锂或5-羟色胺诱导的颤抖行为强度。由于在这些实验中测试的抗癫痫药物没有抗胆碱能活性，并且在所用剂量下不能预防电惊厥或戊四氮诱导的癫痫发作，因此似乎卡巴胆碱诱导的WDS可能与惊厥活动有关，并且可能是癫痫发作的初始阶段。
