Lim J I
The Doheny Eye Institute, Los Angeles, California 90033, USA.
Surv Ophthalmol. 1999 Sep-Oct;44(2):95-111. doi: 10.1016/s0039-6257(99)00077-6.
Iatrogenic choroidal neovascularization is an uncommon complication of laser photocoagulation and other ocular surgical procedures. It appears to be the result of a number of conditions, including damaged Bruch's membrane and/or retinal pigment epithelium, whose reparative processes trigger the release of angiogenic factors. Inflammatory cells and choroidal ischemia may also play a role. The prognosis varies depending on the underlying disease and the type of choroidal neovascularization (subretinal, chorioretinal, or choriovitreal). Minimizing the amount of laser energy used during laser procedures, avoiding repeat laser treatment to the same retinal area, and minimizing direct mechanical trauma to the retinal pigment epithelium and choroid decrease the chance of inducing iatrogenic choroidal neovascularization.
医源性脉络膜新生血管形成是激光光凝和其他眼科手术中一种不常见的并发症。它似乎是多种情况导致的结果,包括布鲁赫膜和/或视网膜色素上皮受损,其修复过程会触发血管生成因子的释放。炎症细胞和脉络膜缺血也可能起作用。预后因潜在疾病和脉络膜新生血管形成的类型(视网膜下、脉络膜视网膜或脉络膜玻璃体)而异。在激光手术过程中尽量减少激光能量的使用量,避免对同一视网膜区域进行重复激光治疗,并尽量减少对视网膜色素上皮和脉络膜的直接机械损伤,可降低诱发医源性脉络膜新生血管形成的几率。