Maruko Ichiro, Koizumi Hideki, Hasegawa Taiji, Arakawa Hisaya, Iida Tomohiro
Department of Ophthalmology, Tokyo Women's Medical University School of Medicine, Shinjuku, Tokyo, Japan.
PLoS One. 2017 Aug 29;12(8):e0184112. doi: 10.1371/journal.pone.0184112. eCollection 2017.
To compare the efficacy of the subthreshold micropulse laser (SML) to conventional laser (CL) in treating focal leakages of the retinal pigment epithelium (RPE) in the eyes with central serous chorioretinopathy (CSC).
Twenty-nine eyes of 28 patients with CSC and typical focal leakage were treated with CL or SML. Both treatments were made with a 577 nm yellow laser (CL: NIDEK MC-500, SML: IRIDEX IQ577). The percentage of eyes with a complete resolution, the distance of the laser burns from the fovea, and injury of the RPE after treatment were studied.
A complete resolution was seen in 10 of 15 eyes (66.7%) after CL and 9 of 14 eyes (64.3%) after SML (P = 0.89). The average distance from the foveal center to the leakage point was 1282±596 μm for eyes treated with CL and 1271±993 μm for eyes treated with SML (P = 0.4). Only three eyes treated with SML had treatment sites within 500 μm of the fovea. RPE damage determined by fundus autofluorescence was found in all eyes treated with CL and only one eye treated with SML (P<.01).
SML achieved equivalent therapeutic effects as CL but without RPE damage in eyes with CSC.
比较阈下微脉冲激光（SML）与传统激光（CL）治疗中心性浆液性脉络膜视网膜病变（CSC）患者视网膜色素上皮（RPE）局灶性渗漏的疗效。
对28例患有CSC且有典型局灶性渗漏的患者的29只眼进行CL或SML治疗。两种治疗均使用577 nm黄色激光（CL：NIDEK MC - 500，SML：IRIDEX IQ577）。研究完全消退的眼的百分比、激光烧灼点距黄斑中心凹的距离以及治疗后RPE的损伤情况。
CL治疗后15只眼中有10只（66.7%）完全消退，SML治疗后14只眼中有9只（64.3%）完全消退（P = 0.89）。接受CL治疗的眼从黄斑中心到渗漏点的平均距离为1282±596μm，接受SML治疗的眼为1271±993μm（P = 0.4）。仅3只接受SML治疗的眼的治疗部位在距黄斑中心凹500μm范围内。通过眼底自发荧光确定的RPE损伤在所有接受CL治疗的眼中均有发现，而在接受SML治疗的眼中仅1只眼出现（P<0.01）。
在CSC患者中，SML与CL取得了同等的治疗效果，但未造成RPE损伤。
