Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Int J Mol Sci. 2021 Jun 8;22(12):6207. doi: 10.3390/ijms22126207.
Retinal diseases are the leading cause of irreversible blindness. They affect people of all ages, from newborns in retinopathy of prematurity, through age-independent diabetic retinopathy and complications of retinal detachment, to age-related macular degeneration (AMD), which occurs mainly in the elderly. Generally speaking, the causes of all problems are disturbances in blood supply, hypoxia, the formation of abnormal blood vessels, and fibrosis. Although the detailed mechanisms underlying them are varied, the common point is the involvement of Eph receptors and ephrins in their pathogenesis. In our study, we briefly discussed the pathophysiology of the most common retinal diseases (diabetic retinopathy, retinopathy of prematurity, proliferative vitreoretinopathy, and choroidal neovascularization) and collected available research results on the role of Eph and ephrins. We also discussed the safety aspect of the use of drugs acting on Eph and ephrin for ophthalmic indications.
视网膜疾病是导致不可逆性失明的主要原因。它们影响所有年龄段的人群，从早产儿视网膜病变中的新生儿，到与年龄无关的糖尿病性视网膜病变和视网膜脱离的并发症，再到主要发生在老年人中的年龄相关性黄斑变性（AMD）。一般来说，所有问题的原因都是血液供应紊乱、缺氧、异常血管的形成和纤维化。尽管它们的详细机制各不相同，但共同点是 Eph 受体和 Ephrins 参与了它们的发病机制。在我们的研究中，我们简要讨论了最常见的视网膜疾病（糖尿病性视网膜病变、早产儿视网膜病变、增生性玻璃体视网膜病变和脉络膜新生血管形成）的病理生理学，并收集了 Eph 和 Ephrins 作用的现有研究结果。我们还讨论了作用于 Eph 和 Ephrins 的药物用于眼科适应症的安全性方面。
