• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The structure of the llama heavy chain constant genes reveals a mechanism for heavy-chain antibody formation.

作者信息

Woolven B P, Frenken L G, van der Logt P, Nicholls P J

机构信息

Biorecognition Unit, Unilever Research, Colworth House, Sharnbrook, Bedfordshire, MK44 1LQ, UK.

出版信息

Immunogenetics. 1999 Oct;50(1-2):98-101. doi: 10.1007/s002510050694.

DOI:10.1007/s002510050694
PMID:10541815
Abstract
摘要

相似文献

1
The structure of the llama heavy chain constant genes reveals a mechanism for heavy-chain antibody formation.羊驼重链恒定基因的结构揭示了重链抗体形成的机制。
Immunogenetics. 1999 Oct;50(1-2):98-101. doi: 10.1007/s002510050694.
2
Sequence of a rat immunoglobulin gamma 2c heavy chain constant region cDNA: extensive homology to mouse gamma 3.大鼠免疫球蛋白γ2c重链恒定区cDNA的序列：与小鼠γ3高度同源。
Eur J Immunol. 1988 Feb;18(2):317-9. doi: 10.1002/eji.1830180222.
3
Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies.剪接共有序列信号的缺失导致功能性骆驼IgG2A重链抗体的整个C(H)1结构域被去除。
Mol Immunol. 1999 Jun;36(8):515-24. doi: 10.1016/s0161-5890(99)00067-x.
4
Sigma region located between C mu and C delta genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing.人免疫球蛋白重链Cμ和Cδ基因之间的西格玛区域：类似tRNA结构在RNA剪接中的可能作用。
Nucleic Acids Res. 1988 Oct 25;16(20):9497-511. doi: 10.1093/nar/16.20.9497.
5
Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea.在一种原始的软骨鱼——猬鳐（Raja erinacea）中发现的两种不同的免疫球蛋白重链同种型。
Nucleic Acids Res. 1990 Nov 11;18(21):6369-76. doi: 10.1093/nar/18.21.6369.
6
A second Xenopus immunoglobulin heavy chain constant region isotype gene.第二种非洲爪蟾免疫球蛋白重链恒定区同种型基因。
Nucleic Acids Res. 1989 Apr 11;17(7):following 2886.
7
Emergence and evolution of functional heavy-chain antibodies in Camelidae.骆驼科功能性重链抗体的出现与进化。
Dev Comp Immunol. 2003 Feb;27(2):87-103. doi: 10.1016/s0145-305x(02)00071-x.
8
Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.人类免疫球蛋白γ3重链恒定区基因序列：与其他人类Cγ基因的比较。
Nucleic Acids Res. 1986 Feb 25;14(4):1779-89. doi: 10.1093/nar/14.4.1779.
9
Organization of immunoglobulin heavy chain constant and joining region genes in the channel catfish.斑点叉尾鮰免疫球蛋白重链恒定区和连接区基因的组织
Mol Immunol. 1992 Feb;29(2):151-9. doi: 10.1016/0161-5890(92)90096-g.
10
Expression and production of llama variable heavy-chain antibody fragments (V(HH)s) by Aspergillus awamori.泡盛曲霉表达和产生羊驼可变重链抗体片段（V(HH)s）
Appl Microbiol Biotechnol. 2005 Jan;66(4):384-92. doi: 10.1007/s00253-004-1689-0. Epub 2004 Sep 17.

引用本文的文献

1
Single domain antibody: Development and application in biotechnology and biopharma.单域抗体：在生物技术和生物制药中的开发与应用。
Immunol Rev. 2024 Nov;328(1):98-112. doi: 10.1111/imr.13381. Epub 2024 Aug 21.
2
Single-cell 5' RNA sequencing of camelid peripheral B cells provides insights into cellular basis of heavy-chain antibody production.骆驼科外周血B细胞的单细胞5'RNA测序为重链抗体产生的细胞基础提供了见解。
Comput Struct Biotechnol J. 2024 Apr 16;23:1705-1714. doi: 10.1016/j.csbj.2024.04.041. eCollection 2024 Dec.
3
NANOBODIES®: A Review of Diagnostic and Therapeutic Applications.
NANOBODIES®：诊断和治疗应用的综述。
Int J Mol Sci. 2023 Mar 22;24(6):5994. doi: 10.3390/ijms24065994.
4
The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics.治疗性单克隆抗体和抗体片段的拼图——从全长免疫球蛋白到抗体模拟物的模块化转变。
Leuk Res Rep. 2022 Jun 27;18:100335. doi: 10.1016/j.lrr.2022.100335. eCollection 2022.
5
Nanobodies: From Serendipitous Discovery of Heavy Chain-Only Antibodies in Camelids to a Wide Range of Useful Applications.纳米抗体：从偶然发现骆驼科动物重链抗体到广泛应用
Methods Mol Biol. 2022;2446:3-17. doi: 10.1007/978-1-0716-2075-5_1.
6
Application of Single-Domain Antibodies ("Nanobodies") to Laboratory Diagnosis.单域抗体（“纳米抗体”）在实验室诊断中的应用。
Ann Lab Med. 2021 Nov 1;41(6):549-558. doi: 10.3343/alm.2021.41.6.549.
7
The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics.骆驼适应性免疫受体库作为结构和功能基因组学的一个独特范例。
Front Genet. 2019 Oct 17;10:997. doi: 10.3389/fgene.2019.00997. eCollection 2019.
8
Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.羊驼外周血 B 细胞中产生常规和重链仅有型 IgG 亚型的细胞表型无法区分，但免疫原性不同。
Immunogenetics. 2019 Apr;71(4):307-320. doi: 10.1007/s00251-018-01102-9. Epub 2019 Jan 18.
9
Distinct antibody species: structural differences creating therapeutic opportunities.不同的抗体种类：结构差异带来治疗机遇。
Curr Opin Immunol. 2016 Jun;40:7-13. doi: 10.1016/j.coi.2016.02.003. Epub 2016 Feb 27.
10
Contributions of conventional and heavy-chain IgG to immunity in fetal, neonatal, and adult alpacas.传统IgG和重链IgG对胎儿、新生儿及成年羊驼免疫的贡献。
Clin Vaccine Immunol. 2010 Dec;17(12):2007-15. doi: 10.1128/CVI.00287-10. Epub 2010 Oct 6.