羊驼重链恒定基因的结构揭示了重链抗体形成的机制。 - Suppr

Suppr

超能文献

The structure of the llama heavy chain constant genes reveals a mechanism for heavy-chain antibody formation.

作者信息

Woolven B P, Frenken L G, van der Logt P, Nicholls P J

机构信息

Biorecognition Unit, Unilever Research, Colworth House, Sharnbrook, Bedfordshire, MK44 1LQ, UK.

出版信息

Immunogenetics. 1999 Oct;50(1-2):98-101. doi: 10.1007/s002510050694.

DOI:10.1007/s002510050694

PMID:10541815

Abstract

摘要

相似文献

The structure of the llama heavy chain constant genes reveals a mechanism for heavy-chain antibody formation.羊驼重链恒定基因的结构揭示了重链抗体形成的机制。

Immunogenetics. 1999 Oct;50(1-2):98-101. doi: 10.1007/s002510050694.

Sequence of a rat immunoglobulin gamma 2c heavy chain constant region cDNA: extensive homology to mouse gamma 3.大鼠免疫球蛋白γ2c重链恒定区cDNA的序列：与小鼠γ3高度同源。

Eur J Immunol. 1988 Feb;18(2):317-9. doi: 10.1002/eji.1830180222.

Loss of splice consensus signal is responsible for the removal of the entire C(H)1 domain of the functional camel IGG2A heavy-chain antibodies.剪接共有序列信号的缺失导致功能性骆驼IgG2A重链抗体的整个C(H)1结构域被去除。

Mol Immunol. 1999 Jun;36(8):515-24. doi: 10.1016/s0161-5890(99)00067-x.

Sigma region located between C mu and C delta genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing.人免疫球蛋白重链Cμ和Cδ基因之间的西格玛区域：类似tRNA结构在RNA剪接中的可能作用。

Nucleic Acids Res. 1988 Oct 25;16(20):9497-511. doi: 10.1093/nar/16.20.9497.

Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea.在一种原始的软骨鱼——猬鳐（Raja erinacea）中发现的两种不同的免疫球蛋白重链同种型。

Nucleic Acids Res. 1990 Nov 11;18(21):6369-76. doi: 10.1093/nar/18.21.6369.

A second Xenopus immunoglobulin heavy chain constant region isotype gene.第二种非洲爪蟾免疫球蛋白重链恒定区同种型基因。

Nucleic Acids Res. 1989 Apr 11;17(7):following 2886.

Emergence and evolution of functional heavy-chain antibodies in Camelidae.骆驼科功能性重链抗体的出现与进化。

Dev Comp Immunol. 2003 Feb;27(2):87-103. doi: 10.1016/s0145-305x(02)00071-x.

Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.人类免疫球蛋白γ3重链恒定区基因序列：与其他人类Cγ基因的比较。

Nucleic Acids Res. 1986 Feb 25;14(4):1779-89. doi: 10.1093/nar/14.4.1779.

Organization of immunoglobulin heavy chain constant and joining region genes in the channel catfish.斑点叉尾鮰免疫球蛋白重链恒定区和连接区基因的组织

Mol Immunol. 1992 Feb;29(2):151-9. doi: 10.1016/0161-5890(92)90096-g.

Expression and production of llama variable heavy-chain antibody fragments (V(HH)s) by Aspergillus awamori.泡盛曲霉表达和产生羊驼可变重链抗体片段（V(HH)s）

Appl Microbiol Biotechnol. 2005 Jan;66(4):384-92. doi: 10.1007/s00253-004-1689-0. Epub 2004 Sep 17.

引用本文的文献

Single domain antibody: Development and application in biotechnology and biopharma.单域抗体：在生物技术和生物制药中的开发与应用。

Immunol Rev. 2024 Nov;328(1):98-112. doi: 10.1111/imr.13381. Epub 2024 Aug 21.

Single-cell 5' RNA sequencing of camelid peripheral B cells provides insights into cellular basis of heavy-chain antibody production.骆驼科外周血B细胞的单细胞5'RNA测序为重链抗体产生的细胞基础提供了见解。

Comput Struct Biotechnol J. 2024 Apr 16;23:1705-1714. doi: 10.1016/j.csbj.2024.04.041. eCollection 2024 Dec.

NANOBODIES®: A Review of Diagnostic and Therapeutic Applications.NANOBODIES®：诊断和治疗应用的综述。

Int J Mol Sci. 2023 Mar 22;24(6):5994. doi: 10.3390/ijms24065994.

The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics.治疗性单克隆抗体和抗体片段的拼图——从全长免疫球蛋白到抗体模拟物的模块化转变。

Leuk Res Rep. 2022 Jun 27;18:100335. doi: 10.1016/j.lrr.2022.100335. eCollection 2022.

Nanobodies: From Serendipitous Discovery of Heavy Chain-Only Antibodies in Camelids to a Wide Range of Useful Applications.纳米抗体：从偶然发现骆驼科动物重链抗体到广泛应用

Methods Mol Biol. 2022;2446:3-17. doi: 10.1007/978-1-0716-2075-5_1.

Application of Single-Domain Antibodies ("Nanobodies") to Laboratory Diagnosis.单域抗体（“纳米抗体”）在实验室诊断中的应用。

Ann Lab Med. 2021 Nov 1;41(6):549-558. doi: 10.3343/alm.2021.41.6.549.

The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics.骆驼适应性免疫受体库作为结构和功能基因组学的一个独特范例。

Front Genet. 2019 Oct 17;10:997. doi: 10.3389/fgene.2019.00997. eCollection 2019.

Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.羊驼外周血 B 细胞中产生常规和重链仅有型 IgG 亚型的细胞表型无法区分，但免疫原性不同。

Immunogenetics. 2019 Apr;71(4):307-320. doi: 10.1007/s00251-018-01102-9. Epub 2019 Jan 18.

Distinct antibody species: structural differences creating therapeutic opportunities.不同的抗体种类：结构差异带来治疗机遇。

Curr Opin Immunol. 2016 Jun;40:7-13. doi: 10.1016/j.coi.2016.02.003. Epub 2016 Feb 27.

Contributions of conventional and heavy-chain IgG to immunity in fetal, neonatal, and adult alpacas.传统IgG和重链IgG对胎儿、新生儿及成年羊驼免疫的贡献。

Clin Vaccine Immunol. 2010 Dec;17(12):2007-15. doi: 10.1128/CVI.00287-10. Epub 2010 Oct 6.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验