人类免疫球蛋白γ3重链恒定区基因序列：与其他人类Cγ基因的比较。
Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.
作者信息
Huck S, Fort P, Crawford D H, Lefranc M P, Lefranc G
出版信息
Nucleic Acids Res. 1986 Feb 25;14(4):1779-89. doi: 10.1093/nar/14.4.1779.
Abstract
We report the first and complete nucleotide sequence of a human gamma 3 heavy chain constant region gene (C gamma 3). This gene displays the same organization than the others C gamma genes and exhibits normal RNA splice and polyadenylation sites. A comparison of its primary sequence with those of C gamma 1, C gamma 2 and C gamma 4 genes confirms the high degree of homology (95%) of the human family in both coding and non-coding regions, and the divergence of the hinge region. The C gamma 3 gene we sequenced codes for a Gm(b) gamma 3 chain (EZZ). Comparison with other known protein sequences reveals that only two specific aminoacids are involved in the Gm(b) and Gm(g) allotypes, which suggests an important part of the spatial configuration in the allotypic specificities.
摘要
我们报道了人类γ3重链恒定区基因（Cγ3）的首个完整核苷酸序列。该基因与其他Cγ基因具有相同的组织结构，并具有正常的RNA剪接和聚腺苷酸化位点。将其一级序列与Cγ1、Cγ2和Cγ4基因的序列进行比较，证实了人类基因家族在编码区和非编码区均具有高度同源性（95%），以及铰链区的差异。我们测序的Cγ3基因编码Gm(b)γ3链（EZZ）。与其他已知蛋白质序列的比较表明，Gm(b)和Gm(g)同种异型仅涉及两个特定氨基酸，这表明空间构型在同种异型特异性中起重要作用。
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