Narbonne J F, Daubèze M, Gillet G
Toxicol Eur Res. 1978 Jul;1(4):229-36.
In the first experiment, rats fed diet containing Phenoclor DP6 at a level of 100 ppm (wet weigh) were sacrificed after 1, 3, 8, 15 and 30 days of treatment. Metabolic alterations such as enlarged liver, increased protein and lipid liver contents and hyperlipemia were established within 8 days. The glucid metabolism and muscle metabolic parameters show a low sensibility to DP6 treatment. In the second experiment, rats fed diet containing Phenoclor DP6 (100 ppm) for 15 days were subsequently removed from the experimental diet and placed on control diet. The metabolic alterations described above disappear within 52 days after removal DP6 diet, although the remaining liver PCB stays elevated. These data attest the early effect of DP6 exposure in rats and the reversibility of induced metabolic alterations.
在第一个实验中，用含有100 ppm（湿重）的二氯二苯醚（Phenoclor DP6）的饲料喂养大鼠，在处理1、3、8、15和30天后将其处死。在8天内出现了诸如肝脏肿大、肝脏蛋白质和脂质含量增加以及高脂血症等代谢改变。糖代谢和肌肉代谢参数对DP6处理表现出低敏感性。在第二个实验中，用含有二氯二苯醚（Phenoclor DP6，100 ppm）的饲料喂养大鼠15天，随后将其从实验饲料中取出并置于对照饲料中。在去除DP6饲料后52天内，上述代谢改变消失，尽管肝脏中残留的多氯联苯仍保持升高。这些数据证明了DP6暴露对大鼠的早期影响以及诱导的代谢改变的可逆性。
