与其他致病性伯克霍尔德菌属细菌相比，鼻疽伯克霍尔德菌的体外药敏情况
In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp.
作者信息
Kenny D J, Russell P, Rogers D, Eley S M, Titball R W
机构信息
CBD Porton Down, Salisbury, Wilts SP4 OJQ, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2773-5. doi: 10.1128/AAC.43.11.2773.
Abstract
The in vitro antimicrobial susceptibilities of isolates of Burkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities of Burkholderia pseudomallei and Burkholderia cepacia. The antibiotic susceptibility profile of B. mallei resembled that of B. pseudomallei more closely than that of B. cepacia, which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against both B. mallei and B. pseudomallei. Gentamicin was active against B. mallei but not against B. pseudomallei. Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.
摘要
评估了鼻疽伯克霍尔德菌分离株对16种抗生素的体外抗菌敏感性，并与类鼻疽伯克霍尔德菌和洋葱伯克霍尔德菌的敏感性进行了比较。鼻疽伯克霍尔德菌的抗生素敏感性谱与类鼻疽伯克霍尔德菌的更相似，而非洋葱伯克霍尔德菌，这与其在生物化学、抗原性和致病性方面的相似性相符。头孢他啶、亚胺培南、强力霉素和环丙沙星对鼻疽伯克霍尔德菌和类鼻疽伯克霍尔德菌均有活性。庆大霉素对鼻疽伯克霍尔德菌有活性，但对类鼻疽伯克霍尔德菌无活性。因此，临床上已证明对治疗类鼻疽有效的抗生素可能对治疗鼻疽也有效。
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