65株类鼻疽伯克霍尔德菌和鼻疽伯克霍尔德菌对35种抗菌药物的药敏试验
Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents.
作者信息
Thibault F M, Hernandez E, Vidal D R, Girardet M, Cavallo J-D
机构信息
Centre de Recherches du Service de Santé des Armées Emile Pardé, Département de Biologie des Agents Transmissibles, F-38702 La Tronche, France.
出版信息
J Antimicrob Chemother. 2004 Dec;54(6):1134-8. doi: 10.1093/jac/dkh471. Epub 2004 Oct 27.
OBJECTIVES
Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria.
METHODS
MICs were determined by agar dilution in Mueller-Hinton medium.
RESULTS
Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem.
CONCLUSIONS
Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections.
目的
对50株类鼻疽伯克霍尔德菌和15株鼻疽伯克霍尔德菌进行测试，以检测它们对35种抗菌药物的敏感性，其中包括之前未针对这些细菌进行测试的药物。
方法
采用琼脂稀释法在 Mueller-Hinton 培养基中测定最低抑菌浓度（MIC）。
结果
在所测试的抗生素中，亚胺培南、头孢他啶、哌拉西林、哌拉西林/他唑巴坦、多西环素和米诺环素的 MIC 较低。氟喹诺酮类和氨基糖苷类药物活性较差。一株类鼻疽伯克霍尔德菌临床分离株对头孢他啶、阿莫西林/克拉维酸和多西环素耐药，但对亚胺培南仍敏感。
结论
虽然鼻疽伯克霍尔德菌的 MIC 通常较低，但总体结果强调了两种菌耐药性的重要性。所测得的敏感性与目前治疗类鼻疽伯克霍尔德菌和鼻疽伯克霍尔德菌感染的建议一致。
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