Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D
Department of Retrovirology, U.S. Army Component, Bangkok, Thailand.
Antimicrob Agents Chemother. 1999 Nov;43(11):2817-8. doi: 10.1128/AAC.43.11.2817.
Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.
对感染来自泰国北部恙虫病东方体菌株的小鼠和人类给予阿奇霉素，泰国北部存在耐药性恙虫病。阿奇霉素和多西环素使小鼠存活率相当（分别为73%和79%；P>0.5）。两名孕妇使用阿奇霉素后症状、体征和发热迅速缓解。需要进行前瞻性人体试验。
