氯霉素、庆大霉素和环丙沙星对鼠型恙虫病的作用
Chloramphenicol, gentamicin, and ciprofloxacin against murine scrub typhus.
作者信息
McClain J B, Joshi B, Rice R
机构信息
Infectious Disease Service, Walter Reed Army Medical Center, Washington, D.C. 20307.
出版信息
Antimicrob Agents Chemother. 1988 Feb;32(2):285-6. doi: 10.1128/AAC.32.2.285.
Abstract
Ciprofloxacin (120 mg/kg of body weight per day), chloramphenicol (300 mg/kg per day), and gentamicin (30 mg/kg per day) were compared with placebo in a BALB/cj mouse model of scrub typhus. All animals treated with ciprofloxacin and chloramphenicol survived. All animals treated with gentamicin or placebo died. All surviving animals showed evidence of seroconversion. Ciprofloxacin and chloramphenicol were statistically more effective in preventing death than gentamicin or placebo.
摘要
在恙虫病的BALB/cj小鼠模型中，将环丙沙星（每天120毫克/千克体重）、氯霉素（每天300毫克/千克）和庆大霉素（每天30毫克/千克）与安慰剂进行了比较。所有接受环丙沙星和氯霉素治疗的动物均存活。所有接受庆大霉素或安慰剂治疗的动物均死亡。所有存活的动物都有血清转化的证据。在预防死亡方面，环丙沙星和氯霉素在统计学上比庆大霉素或安慰剂更有效。
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本文引用的文献
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