纯结晶1α-羟基维生素D3和1α,25-二羟基维生素D3对肠道钙吸收的快速作用的证明。
Demonstration of the rapid action of pure crystalline 1 alpha-hydroxy vitamin D3 and 1 alpha,25-dihydroxy vitamin D3 on intestinal calcium uptake.
作者信息
Toffolon E P, Pechet M M, Isselbacher K
出版信息
Proc Natl Acad Sci U S A. 1975 Jan;72(1):229-30. doi: 10.1073/pnas.72.1.229.
Abstract
The biological effects of crystalline 1alpha-hydroxyvitamin D3 and crystalline 1alpha,25-dihydroxyvitamin D3 have been compared on the intestinal uptake of calcium-45 by everted duodenal gut sacs from rachitic rats. Peak calcium-45 uptake was observed 1 hr after intravenous administration and both crystalline vitamin D2 analogs were of comparable potency. The rapid onset of calcium-45 uptake and the rapid attainment of maximal calcium-45 transport suggests a direct effect of these crystalline analogs on the mucosal membranes of the intestinal cell.
摘要
已对结晶1α-羟基维生素D3和结晶1α,25-二羟基维生素D3对佝偻病大鼠外翻十二指肠肠囊对钙-45的肠道摄取的生物学效应进行了比较。静脉给药后1小时观察到钙-45摄取峰值，两种结晶维生素D2类似物的效力相当。钙-45摄取的快速起效和最大钙-45转运的快速实现表明这些结晶类似物对肠细胞的粘膜膜有直接作用。
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Demonstration of the rapid action of pure crystalline 1 alpha-hydroxy vitamin D3 and 1 alpha,25-dihydroxy vitamin D3 on intestinal calcium uptake.纯结晶1α-羟基维生素D3和1α,25-二羟基维生素D3对肠道钙吸收的快速作用的证明。
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